Objective:To explore the application value of 3D printing technology in tumor resection surgery in the diagnosis and treatment of liver tumor patients.Methods:A retrospective analysis was conducted on the data of 80 patients with liver tumors,sourced from January 2021 to December 2023.Grouping based on different surgical plans:the control group(n=40) underwent open liver resection,while the observation group(n=40) underwent open liver resection under 3D printing guidance.The intraoperative surgery time,bleeding volume,postoperative hospital stay,liver failure,bile leakage,and other indicators of the two groups of patients were evaluated.Results:① Compared with the control group,the observation group had shorter surgical time,postoperative time to get out of bed,postoperative hospital stay,and hepatic portal block time.The intraoperative bleeding volume and excised liver volume were smaller,and the peak values of total bilirubin and alanine aminotransferase were lower (P<0.05).②The incidence of complications in the observation group was slightly lower than that in the control group,but there was no statistical difference (7.50%,17.50%,P>0.05).Conclusion:The use of 3D printing technology during hepatectomy in patients with liver tumors can accurately remove lesions and reduce intraoperative bleeding;At the same time,it can also reduce the incidence of complications and promote postoperative recovery.