Objective:To investigate the value of color ultrasonography in the differential diagnosis of hepatocellular carcinoma (HCC) and hepatic hemangioma. Methods:68 patients with hepatocellular carcinoma diagnosed in our hospital from July 2021 to July 2023 were retrospectively selected as liver cancer group,and another 68 patients with hepatic hemangioma at the same period were selected as liver hemangioma group. Color Doppler ultrasonography and CT examination were performed respectively to compare the diagnostic results and diagnostic efficacy of the two groups. Results:Compared with hepatic hemangioma,the proportion of clear boundary,regular shape and uniform internal echo was lower in HCC group,and the proportion of occupying effect was higher (P<0.05). The internal and peripheral blood flow abundances were higher in HCC group (P<0.05). Hepatic portal vein flow velocity was lower in HCC group,and the minimum flow velocity and peak flow velocity of proper hepatic artery were higher (P<0.05). The diagnostic sensitivity and accuracy of ultrasound for hepatocellular carcinoma and hepatic hemangioma were higher than those of conventional CT,and the rate of missed diagnosis was lower than that of conventional CT (P<0.05). Conclusion:Color Doppler ultrasound can be used in the differential diagnosis of hepatocellular carcinoma (HCC) and hepatic hemangioma. Ultrasound imaging features and blood flow status can be used to assist early diagnosis to improve diagnostic accuracy.