摘要
目的探讨同步放化疗治疗中晚期宫颈癌的疗效.方法86例中晚期宫颈鳞癌放疗患者随机分为同步放化疗组(n=46)、单纯放疗组(n=40)，观察两组治疗效果及副反应并比较分析.结果放疗结束时两组有效率分别为100%、97.50%，差异无统计学意义(P >0.05).两组5年生存率、局部复发率和远处转移率比较，差异有统计学意义(P <0.05).同步放化疗组有较明显的骨髓抑制及胃肠道反应，与单纯放疗组比较差异有统计学意义(P <0.05)，远期不良反应发生率两组差异无统计学意义(P >0.05).结论同步放化疗与单纯放疗比较，能明显提高患者的5年生存率，降低患者的局部复发率和远处复发率.同步放化疗组有较明显的骨髓抑制和消化道反应，但患者经治疗后均可耐受.
Abstract
Objective To investigate chemotherapy method of concurrent chemotherapy and radiotherapy on medium and advanced stage cervical cancer1. Methods The 86 cases with medium and advanced stage cervical cancer treated by concurrent chemotherapy and radiotherapy were randomized into two groups: concurrent chemotherapy and radiotherapy group(46 cases), radiotherapy group(40 cases). The curative effective and side effect were observed and compared. Results Effective rate was 100%, 97.50% in concurrent chemotherapy and radiotherapy group and radiotherapy group, with no significant difference among them(P >0.05). The rate of five year survival, local recurrence, and distant metastasis was 69.57%,19.57%, and 17.39% respectively in concurrent chemotherapy and radiotherapy group, higher than radiotherapy group 55.00%, 42.50%, 40.00%). There was significant difference between the two groups(P <0.05). There was obviously bone marrow inhibition and side-effect of digestive tract in concurrent chemotherapy and radiotherapy group compared to radiotherapy group(P <0.05). Conclusions Concurrent chemotherapy and radiotherapy can significantly improve the patients' survival, reduce the local recurrence and distant metastasis with less side effect in medium and advanced stage cervical cancer.
NETL
NSTL
维普
万方数据