摘要
目的探讨联合检测血清和胸水中癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角质蛋白19片断(CYFRA21-1)对良恶性胸腔积液的鉴别诊断价值.方法96例临床已确诊的胸腔积液患者(恶性组50例，良性组46例)采用全自动免疫分析系统进行CEA、NSE、CYFRA21-1含量测定.结果恶性胸腔积液患者的3种肿瘤标志物水平均明显高于良性疾病组，差异有统计学意义(P <0.05).联合检测血清及胸腔积液3项指标，恶性胸腔积液诊断的敏感性为98%，特异性为80%，准确性为89%，较检测单一指标提高了诊断的敏感度、准确度.结论联合检测胸腔积液中CEA、NSE、CYFRA21-1对良恶性胸腔积液的鉴别诊断有重要价值，能提高诊断准确率.
Abstract
Objective To discuss detection of CEA,NSE and CYFRA21-1 in serum and pleural fluid for differentiation of benign from malignant pleural fluid diagnosis value. Methods Determination of content of CEA, NSE, CYFRA21-1 by using electrochemiluminescence immunoassay kit in 96 cases of patients with pleural fluid(the malignant group 50 cases, the benign group 46 cases). Results Levels of 3 tumor markers of patients with malignant pleural effusions were significantly higher than those of patients with benign ones(P <0.05). Detection of serum and pleural effusion in 3 indicators, the sensitivity of diagnosis for malignant pleural effusion was 98%, the specificity was 80%, the accuracy was 89%. Improves diagnostic sensitivity, accuracy than detection of single index. Conclusion Combined detection of pleural effusion in CEA, NSE, CYFRA21-1 in he differential diagnosis of benign from malignant pleural effusions have important value, improve the accuracy of diagnosis.
NETL
NSTL
维普
万方数据