Expression and role of CIP2A in myelodysplastic syndromes(MDS)
Objective To investigate the expression and significance of cancerous inhibitor of protein phosphatase 2A(CIP2A) in myelodysplastic syndromes(MDS). Methods The immunohistochemical SP staining was used to detect expression of CIP2A in control group and in MDS. Result Expression of CIP2A in MDS was significantly higher than that in control group(P <0.05), expression of CIP2A in control group and low-risk group had no significant difference(P >0.05). CIP2A in high-risk group was significantly higher than that in low-risk group(P <0.05). CIP2A in AML group was significantly higher than that in high-risk group(P <0.05). Conclusion The expression of CIP2A is significantly increased in MDS bone marrow mononuclear cells, and the positive expression of CIP2A is associated with the genesis and prognosis of MDS.
NETL
NSTL
万方数据
维普
