Objective Ultrasound guided percutaneous renal biopsy with ultrasound localization after percutaneous renal biopsy with blind wear method in the clinical application of who has more superiority. Methods The hospital treated 100 cases of renal Department of internal medicine in patients with kidney disease, in ultrasound guided renal biopsy, divided into A group; earlier in Guangyuan Hospital were analyzed in 100 patients with renal disease, in the color location after the use of ‘ten' blind wear 1 renal biopsy, were divided into group B. Observation and analysis of the successful rate and the complications of two groups. Results The patients in the A group were a success in 92 cases, two were successful in 96 cases of needle. Success rates were 92%, 96% in B group were a success; in 63 cases, two needle success based on 82 cases, 2 cases failed. Success rates were 63%, 82%. A complication rate 6%; group B 23%complication rate. Conclusion BARD MAGNUM automatic biopsy gun percutaneous ultrasound-guided renal biopsy by ultrasound localization after percutaneous renal biopsy with blind to wear less complications, the risk of small, high success rate.