作者信息
- 1. 125001 辽宁省葫芦岛市中心医院放疗科
- 折叠
摘要
目的观察和评价同步放化疗治疗Ⅲ期非小细胞肺癌的疗效和毒副反应.方法Ⅲ期非小细胞肺癌患者40例,随机分为同步放化疗组和序贯放化疗组,同步放化疗组行三维适形常规分割放疗,总量60-68Gy/30-34次/6-7周；放疗开始后同步进行NP方案化疗,NVB 25mg/m2,d1、8；DDP25mg/m2,d1-3,21d为1个周期,放疗后再采用该方案化疗4个周期.序贯放化疗组的放疗方案、剂量及辅助化疗同同步放化疗组.结果同步放化疗组和序贯放化疗组有效率分别为75.0%和35.0%,1、3年总生存率分别为50.0%、40.0%和40.0%、12.5%,差异有统计学意义.结论 NP方案联合同步放疗治疗Ⅲ期非小细胞肺癌的疗效确切,毒副反应可耐受,值得进一步推广.
Abstract
Objective To observe and evaluate the curative effect and side effects of radiotherapy with concurrent chemotherapy in the treatment of stage Ⅲ non-small cell lung cancer. Methods Select stage Ⅲ non-small cell lung cancer patients forty cases, Randomly divided into two groups and each group twenty cases. The concurrent radiochemotherapy group: conventional fractionated radiation 60-68Gy/30-34f/6-7 weeks, and NVB 25mg/m2, d1, 8; DDP25mg/m2, d1-3, 21d(1 cycle equals 21d),four weeks later, the patients received adjuvant chemotherapy further. Sequential group: the other twenty cases were treated with conventionated radiation and four weeks later received adjuvant chemotherapy, radiation scheme, dose and adjuvant chemotherapy as chemoradiation group. Results The response rates of cocurrent group and sequential group were 75.0% and 35.0%(P <0.05) .The 1-year and 3-year survival rates were 50.0%, 40.0% and 40.0%, 12.5%(P <0.05). Conclusion NP regimen combined synchronous radiation therapy is effective and it is worth further promotion in stage Ⅲ non-small cell lung cancer, and the adverse reaction can be tolerate.
关键词
Ⅲ期非小细胞肺癌/同步/序贯放化疗/NP方案Key words
Ⅲ non-small cell lung cancer/Concurrent radiochemotherapy/Sequential radiochemotherapy/NP regimen引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据