Objective To observe and evaluate the curative effect and side effects of radiotherapy with concurrent chemotherapy in the treatment of stage Ⅲ non-small cell lung cancer. Methods Select stage Ⅲ non-small cell lung cancer patients forty cases, Randomly divided into two groups and each group twenty cases. The concurrent radiochemotherapy group: conventional fractionated radiation 60-68Gy/30-34f/6-7 weeks, and NVB 25mg/m2, d1, 8; DDP25mg/m2, d1-3, 21d(1 cycle equals 21d),four weeks later, the patients received adjuvant chemotherapy further. Sequential group: the other twenty cases were treated with conventionated radiation and four weeks later received adjuvant chemotherapy, radiation scheme, dose and adjuvant chemotherapy as chemoradiation group. Results The response rates of cocurrent group and sequential group were 75.0% and 35.0%(P <0.05) .The 1-year and 3-year survival rates were 50.0%, 40.0% and 40.0%, 12.5%(P <0.05). Conclusion NP regimen combined synchronous radiation therapy is effective and it is worth further promotion in stage Ⅲ non-small cell lung cancer, and the adverse reaction can be tolerate.
NETL
NSTL
万方数据
维普
