Concurrent three dimension conformal radiotherapy and chemotherapy followed by consolidation chemotherapy for Esophageal carcinoma
Objective To investigate the comprehensive treatment of Esophageal carcinoma, and to compare the efficacy and toxicity of concurrent chemoradiotherapy. Methods One hundred and eleven patients with esopheageal cancer were randomly divided into two groups: Group A: 59 patients were given concurrent CDDP plus 5-FU or CDDP plus TOXITACEL and radiotherapy(CRT). Group B: 52 patients were treated by radiotherapy alone(RT). Results In Group B, the complete response rate, partial response rate, overall response rate, and the 1-,3-,5-year survival rates were better than Group A. Concurrent chemoradiotherapy can increase the overall response rate, reduce the local aborted rate, and it is safe and effective The difference between group A and B was statistically significant. Conclusions The 3-4 grade radiation pneumonitis and radiation esophagitis in Group A was higher than Group B, but it is tolerable. Concurrent chemoradiotherapy can increase the overall response rate, reduce the local aborted rate,and it is safe and effective to esophageal carcinoma patients either inoperable or who refused operation.
NETL
NSTL
万方数据
维普
