Breast cancer mammography X-ray findings with the expression of molecular biology research
Objective Biology explore breast cancer mammography X-ray findings with the cancer cells of the estrogen receptor(ER) and progesterone receptor(PR) and human tumor suppressor gene(P53), aimed at early diagnosis and prognosis of breast provide the basis. Methods A retrospective analysis of 152 patients with pathologically proved infiltrating ductal breast cancer study. The patients preoperative mammography X-ray examination focus observed increased lesion mass, calcification, structural disorder, local density. To histopathological results do control. Postoperative specimens Determination ER, PR, P53 expression analysis of the relationship between them with X-ray mammography performance. Results 152 cases of invasive ductal carcinoma, showed a mass with irregular burrs or form associated with the expression of ER, PR(χ2=8.108, P<0.05; χ2=5.571, P<0.05); Calcification significant difference in expression of ER, PR(χ2=4.851, P<0.05; χ2=4.579, P<0.05); Increased breast structural disorder or local density and ER, PR expression difference was statistically significant(χ2=6.521, P<0.05; χ2=5.602, P<0.05). Breast structural disorder or increased local density and P53 expression significant difference(χ2=7.883, P<0.05). Conclusion Breast cancer mammography X-ray findings exists a certain correlation between ER, PR, P53, to some extent, reflect the biological behavior and prognosis of breast cancer cells, to provide more for the early diagnosis and treatment objective basis.
Breast cancerMammography X-ray photographyMolecular markers
NETL
NSTL
万方数据
维普
