Effect of Dexmedetomidine on Clinical Profiles in elderly Patients in the Period of Tracheal Extubation
Objective To determine the effect of administration of dexmedetomidine by the end of operation on clinical profiles in the period of tracheal extubation in general anesthesia elderly patients. Methods 40 elderly patients who were undergoing Femoral fractures surgery with open reduction and internal fixation were randomly divided into dexmedetomidine group(group D) or control group(group C). The scheme of induction and maintenance of anesthesia of the two groups were identical. Patients in group D were administered dexmedetomidine at a dose of 0.5μg/kg over 10min and in group C patients were given a placebo infusion of normal saline at identical rates at 10min by the end of the operation. Systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR), pulse oxygen saturation(SpO2), end-tidal carbon dioxide pressure(PETCO2), extubation time and Ramsay score, VAS score, Agitation score were recorded at ending operation(T1), 15min after the operation(T2), extubation(T3), leaving the PACU(T4). Results SBP、DBP、HR in group D were no significantly different at T1,T2,T3 and T4(P>0.05). SBP, DBP, HR in group C were significantly different at T1,T2,T3 and T4(P<0.05). SBP, DBP, HR in group D during peri-extubation were significantly different from those in group C which fluctuated more markedly(P<0.05). SpO2 and PETCO2 in group D during peri-extubation were no significantly different from those in group C(P>0.05). Tolerance score to endotracheal tube in group D was superior to that in group C(P<0.05). Conclusions Dexmedetomidine could effectively reduce the cardiovascular response to, together with retaining the awakened power of patients under active sedation. It's analgesic effect is strong but without respiratory depression.
DexmedetomidineExtubation in elderly patientsRamsayVASAgitation scale
NETL
NSTL
万方数据
维普
