Expression of liver-intestine cadherin and its significance in primary hepatoma
Objective To explore the expression level and clinical significance of LI(liver-intestine)-cadherin in hepatocellular carcinoma. Methods Immunohistochemical staining S-P(streptavidin-peroxidase) method was used to detect the expression of the LI-cadherin in 62 cases of hepatocellular carcinoma, 32 cases of corresponding paracancerous tissues. The relationships with its clinicopathological characteristics were analyzed. Results The positive rates of LI-cadherin protein were 64.5% (40/62) in hepatocellular carcinoma tissues, 26.7% (8/30) in paracancerous tissues. Conclusion The expression of LI-cadherin is up-regulated significantly in HCC. The over-expression of LI-cadherin protein is correlated with the lymph node metastasis and tumor thrombi in portal vein. It indicates that LI-cadherin may play an important role in the hyperplasia ,progression and metastasis of HCC.
Primary hepatomaLiver-intestine cadherinlymph node metastasisTumor thrombi in portal vein
NETL
NSTL
万方数据
维普
