Prognosis influential factor analysis of 27 patients of acquire immunodeficiency syndrome complicated with cryptococcal meningitis
Objective To investigate the clinical features,prognosis and risk factors of patients of acquired immunodeficiency syndrome(AIDS) complicated with cryptococcal meningitis(CM). Methods Totally 27 patients of AIDS with CM who were hospitalized in Changsha Contagious Hospital were enrolled in the study. The clinical data including diagnosis, treatments and prognosis from all the patients were analyzed retrospectively. Results Among the 27 patients entrolled in the study, the positive rate of cerebrospinal fluid india ink smear or Crypotococcus neaformans culture was 100%. The most common symptoms were fever, headache and meningeal irritation sign. The average CD4+lymphocyte count was 40.2/mm3. All the patients showed Concomitant multiple organ infections. The mortality rate was as high as 22%. At the original therapy, the intracranial pressures were remarkably higher in the patients with unfavorable prognosis compared the patients with good prognosis, which was statistically different. Conclusion The results of intracranial pressure test can predict the prognosis. Prompt diagnosis and treatment can decrease death rate of patients. HAART in time of patients reduce relapse rate.
NETL
NSTL
万方数据
维普
