Expression of T lymphocyte subsets and significance in Nasopharyngeal non- keratinizing squamous cell carcinoma
Objective To investigate the expression of T lymphocyte subsets and its significance in nasopharyngeal non-keratinizing squamous cell carcinoma. Methods The immunohistochemistry staining method and Immunohistochemical double staining were used to detect the expression of T lymphocyte subsets in nasopharyngeal carcinoma and nasopharyngeal mucosa with chronic inflammation. Results The differential expression in CD3, CD4, CD8, CD4FoxP3, CD8FoxP3 between Nasopharyngeal carcinoma and Mucosa with chronic inflammation group were statistically significant, P<0.05. CD3+, CD4+FoxP3+ and CD8+FoxP3+ T cells in the differential expression of differentiated non-keratinizing squamous cell carcinoma, and undifferentiated squamous cell carcinoma was statistically significant(P<0.05). Conclusions The change in the number and proportion of T lymphocyte subsets prompted the immune dysfunction in Nasopharyngeal non-keratinizing squamous cell carcinoma and provide good conditions for the development of nasopharyngeal carcinoma. And the different differentiation degree of the tumor cell in nasopharyngeal tumor microenvironment has the different immune status.
Nasopharyngeal carcinomaNasopharyngeal mucosa with chronic inflammationT lymphocyte subsetsCD4CD8
NETL
NSTL
万方数据
维普
