鼻咽非角化鳞状细胞癌组织内T淋巴细胞亚群的变化及意义
Expression of T lymphocyte subsets and significance in Nasopharyngeal non- keratinizing squamous cell carcinoma
张志兴 1马韵 1陆会平1
作者信息
- 1. 530021 南宁，广西医科大学第一附属医院病理科
- 折叠
摘要
目的观察T淋巴细胞亚群在鼻咽非角化鳞状细胞癌中的表达情况,探讨免疫细胞的变化在鼻咽癌发生发展中的意义.方法通过免疫组化SP法和免疫组化双染法检测CD3、CD4、CD8、CD4FoxP3和CD8FoxP3在101例鼻咽癌和21例鼻咽黏膜慢性炎中的表达.结果 CD3、CD4、 CD8、 CD4FoxP3、CD8FoxP3在鼻咽癌组与黏膜慢性炎组之间的表达差异均有统计学意义,P<0.05.CD3+、CD4+FoxP3+、CD8+FoxP3+T细胞在分化型非角化鳞状细胞癌和未分化型鳞状细胞癌中的表达差异有统计学意义,P<0.05.结论鼻咽非角化鳞状细胞癌中,T淋巴细胞亚群数量变化提示了机体免疫功能低下,为鼻咽癌的发生发展提供了良好的条件.不同分化程度的鼻咽癌肿瘤微环境内的免疫状态不同.
Abstract
Objective To investigate the expression of T lymphocyte subsets and its significance in nasopharyngeal non-keratinizing squamous cell carcinoma. Methods The immunohistochemistry staining method and Immunohistochemical double staining were used to detect the expression of T lymphocyte subsets in nasopharyngeal carcinoma and nasopharyngeal mucosa with chronic inflammation. Results The differential expression in CD3, CD4, CD8, CD4FoxP3, CD8FoxP3 between Nasopharyngeal carcinoma and Mucosa with chronic inflammation group were statistically significant, P<0.05. CD3+, CD4+FoxP3+ and CD8+FoxP3+ T cells in the differential expression of differentiated non-keratinizing squamous cell carcinoma, and undifferentiated squamous cell carcinoma was statistically significant(P<0.05). Conclusions The change in the number and proportion of T lymphocyte subsets prompted the immune dysfunction in Nasopharyngeal non-keratinizing squamous cell carcinoma and provide good conditions for the development of nasopharyngeal carcinoma. And the different differentiation degree of the tumor cell in nasopharyngeal tumor microenvironment has the different immune status.
关键词
鼻咽癌/鼻咽黏膜慢性炎/T淋巴细胞亚群/CD4/CD8Key words
Nasopharyngeal carcinoma/Nasopharyngeal mucosa with chronic inflammation/T lymphocyte subsets/CD4/CD8引用本文复制引用
基金项目
出版年
2013
NETL
NSTL
维普
万方数据