Study on changes of Pathological in brain tissues after secondary brain insults with seawater immersion in rats
Objectives To observe the pathological impact of seawater on rats brain tissue after secondary brain insults. Methods Modified rats models of secondary brain insults, in which the damage brain tissues were subjected to immersion with fresh seawater continuously. Tissue sampling was performed at the brain injury sites of Hippocampus. Path-ological changes of traumatic brain edema was observed by hematoxylin and eosin method at designed time points(1h, 3h, 6h, 12h, 48h). Results The brain edema of SBI with seawater immersion is earlier and much serious than SBIgroups, Pathological change by HE method indicated that preinjury traumatic edema was aggravated as a result of seawater immersion and became grid changed not the same as Spongiform change of SBI group. Conclusion SBI with seawater immersion group is more serious than SBI group under the corresponding time window, the deteriorism of traumatic condition in SBI with seawater immersion became more serious quickly.
NETL
NSTL
万方数据
维普
