Clinic significance of solubility intercellular adhesion molecule-1 in coronary heart disease
Objective To study the relationship between serum solubility intercellular adhesion molecule-1 and coronary heart disease. Methods Three groups included 44 cases of acute coronary syndrome, 48 ones of stabile coronary heart disease and 30 ones of normal coronary artery. The level of their serum solubility intercellular adhesion molecule-1 was measured by enzyme-linked immunosorbent assay, the severity and extent of coronary lesion was analyzed by coronary angiography and evaluated by means of Gensini coronary score system. Results The level of serum serum solubility intercellular adhesion molecule-1 increased in coronary heart disease group as compared with normal group. Meanwhile, the level of serum serum solubility intercellular adhesion molecule-1 also increased in acute coronary syndrome group as compared with stabile coronary heart disease group. Positive correlation was found between the severity of coronary lesion and the level of serum serum solubility intercellular adhesion molecule-1. Conclusion Serum solubility intercellular adhesion molecule-1 may be a marker of coronary heart disease, and measurement of this marker may be helpful to diagnosis of coronary plaque destabilization and the severity of coronary heart disease.
NETL
NSTL
万方数据
维普
