血清可溶性细胞间黏附因子-1在冠心病中的发病学意义
Clinic significance of solubility intercellular adhesion molecule-1 in coronary heart disease
李云波 1杨丽霞 2郭瑞威2
作者信息
- 1. 650107 昆明，云南省急救中心医教科
- 2. 成都军区昆明总医院心血管内科
- 折叠
摘要
目的探讨血清可溶性细胞间黏附因子-1水平与冠心病发病的关系。方法92例冠心病患者按临床诊断分为急性冠脉综合症组44例和稳定型冠心病组48例,对照组患者30例,ELISA检测各组患者血清中的可溶性细胞间黏附因子-1水平,并比较各组间的差异；冠脉造影术对冠脉病变进行Gensini评分,并了解其与血清中可溶性细胞间黏附因子-1水平的相关性。结果冠心病患者血清中的可溶性细胞间黏附因子-1水平显著高于正常对照组；并在冠心病组内,急性冠脉综合症组的可溶性细胞间黏附因子-1水平显著高于稳定型冠心病患者；冠脉病变Gensini评分与血清可溶性细胞间黏附因子-1水平有明显的相关性。结论血清可溶性细胞间黏附因子-1水平可能是冠状动脉粥样硬化的一个炎性标志,其参与了冠心病的发病过程,并可以促进斑块不稳定性的发生。
Abstract
Objective To study the relationship between serum solubility intercellular adhesion molecule-1 and coronary heart disease. Methods Three groups included 44 cases of acute coronary syndrome, 48 ones of stabile coronary heart disease and 30 ones of normal coronary artery. The level of their serum solubility intercellular adhesion molecule-1 was measured by enzyme-linked immunosorbent assay, the severity and extent of coronary lesion was analyzed by coronary angiography and evaluated by means of Gensini coronary score system. Results The level of serum serum solubility intercellular adhesion molecule-1 increased in coronary heart disease group as compared with normal group. Meanwhile, the level of serum serum solubility intercellular adhesion molecule-1 also increased in acute coronary syndrome group as compared with stabile coronary heart disease group. Positive correlation was found between the severity of coronary lesion and the level of serum serum solubility intercellular adhesion molecule-1. Conclusion Serum solubility intercellular adhesion molecule-1 may be a marker of coronary heart disease, and measurement of this marker may be helpful to diagnosis of coronary plaque destabilization and the severity of coronary heart disease.
关键词
可溶性细胞间黏附因子-1/急性冠脉综合症,ELISAKey words
Serum solubility intercellular adhesion molecule-1/Acute coronary syndrome/ELISA引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据