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白芍总苷对系统性红斑狼疮治疗作用及不良反应

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目的探讨白芍总苷对系统性红斑狼疮治疗作用及不良反应.方法将41例系统性红斑狼疮患者随机分成观察组和对照组,均给予糖皮质激素和环磷酰胺治疗,观察组在此基础上加用白芍总苷,观察两组患者日平均糖皮质激素用量、环磷酰胺总量、SLEDAL评分、尿蛋白、复发例数及不良反应病例,对比分析临床疗效.结果两组患者日糖皮质激素平均用量、环磷酰胺总量、SLEDAL评分、复发例数及不良反应发生率比较具有明显差异,P <0.05.两组尿蛋白比较无明显差异,P >0.05.结论白芍总苷治疗系统性红斑狼疮疗效确切,可有效减少患者糖皮质激素和环磷酰胺用量,降低感染发生,长期服用可有效改善患者临床症状,提高生存质量.
Objective To explore the effect of total glucosides of glycoside on systemic lupus erythematosus therapeutic effects and adverse reactions. Methods 41 cases of patients with systemic lupus erythematosus, were randomly divided into observation group and control group, two groups of patients were given corticosteroid and cyclophosphamide treatment, the observation group based on this combined with total glucosides of peony, observe two groups of patients with mean daily dosage of corticosteroid and cyclophosphamide, total volume, SLEDAL score, urinary protein, recurrence the number of cases and cases of adverse reactions, comparative analysis of the clinical therapeutic effect. Results The two groups of patients on corticosteroid dosage of cyclophosphamide, average, total score of SLEDAL, cases of relapse and the incidence of adverse reaction, compared with the difference, P <0.05.The two groups showed no significant difference of urine protein, P >0.05. Conclusion The total glucosides of peony in the treatment of systemic lupus erythematosus curative effect, which can effectively reduce the patients with corticosteroid and cyclophosphamide dosage, reduce the infection, long-term use can improve clinical symptoms, improve quality of life.

Total Glucosides of peonySystemic lupus erythematosusTherapeutic effectAdverse reaction

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526000 广东省肇庆市第一人民医院

白芍总苷 系统性红斑狼疮 治疗作用 不良反应

2013

中国医疗前沿
中国医院协会

中国医疗前沿

影响因子:0.186
ISSN:1673-5552
年,卷(期):2013.(6)
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