阿仑膦酸钠治疗绝经后骨质疏松症的疗效分析
古东海 1张妍 1吴凤玲1
作者信息
- 1. 525000 广东省茂名市人民医院内分泌科
- 折叠
摘要
目的分析阿仑膦酸钠治疗绝经后骨质疏松症的临床疗效.方法将80例绝经后骨质疏松患者随机分成观察组和对照组,观察组给予阿伦膦酸钠片,10mg/d,对照组给予安慰剂,两组患者均同时加服钙尔奇D600,以6个月为一个疗程,连续治疗12个月.观察两组患者治疗前后骨密度和骨代谢指标、新骨折发生情况及临床不良反应.结果两组患者经2个疗程治疗后,骨密度、血骨钙素、C端交联多肽水平变化比较具有统计学意义,P <0.05；两组患者均未见新骨折发生和明显不良反应.结论阿伦磷酸钠治疗绝经后骨质疏松症具有明显的抑制骨吸收作用,能够减少绝经后妇女腰椎骨量的流失,副作用较少,是绝经后妇女预防和治疗骨质疏松的理想药物.
Abstract
Objective To analyse the curative effect of alendronate sodium in treating the postmenopausal osteoporosis patients. Methods A total of 80 patients with postmenopausal osteoporosis were randomly divided into observation group and control group, the observation group accepted a treatment with Alendronate Sodium Tablets, while the control group was given a treatment with placebo, Caltrate 600-D was added to patients in both groups for 12 months(6months as a course of treatment). Patients in two groups were observed before and after the treatment, changes of bone mineral density, bone metabolic markers, new fracture incidence and clinical adverse reaction were compared. Results After 2 courses of treatment, the comparison of bone mineral density, serum osteocalcin, C end peptide levels in the two groups had statistical significance, P <0.05; no new fractures and any obvious adverse reaction occurred in both groups. Conclusion Allen phosphoric acid sodium was good at treating the postmenopausal osteoporosis, with its obvious function of inhibiting bone resorption. It was also capable of reducing the vertebral bone loss in postmenopausal women, with fewer side effects. It might be a ideal drug in postmenopausal women for prevention and treatment of osteoporosis.
关键词
阿仑膦酸钠/骨质疏松症/临床治疗Key words
Alendronate/Osteoporosis/Clinical treatment引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据