Objective To explore the association of metabolic syndrome and bone metabolism. Methods All subjects were enrolled from inpatients who underwent osteoporosis. We studied total of 86 patients. Measurement bone mineral density(BMD) of the lumbar spine,femoral neck and left forearm with Dual Energy X-ray Absorptiometry were performed. Divided into three groups according to bone mineral density: normal, dsreduced bone mass and osteoporosis, fasting blood glucose with RIA meanwhile were recorded TG, HDL and other biochemical markers. Results FPG, TG and so on were higher than in normal group, Serum adiponectin levels in dsreduced bone mass group and osteoporosis group were lower than in normal group(P<0.05). In stepwise multiple linear regression analysis APN, TG, HOMA-IR could enter into the equation(P<0.05). Incidence of osteoporosis was higher than the control group. Conclusion TG and HOMA-IR are influencial factors of osteoporosis, Metabolic syndrome as the aggregate of multiple metabolic disorders was prone to osteoporosis.