首页|代谢综合征患者血清脂联素水平变化与骨密度相关性研究

代谢综合征患者血清脂联素水平变化与骨密度相关性研究

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目的研究老年人群中骨质疏松与代谢综合征之间的内在联系,探讨脂联素水平与骨质疏松、代谢综合征疾病严重程度相关性及与血生化指标相互作用.方法选取入院患者86例,测定其正位腰椎、左右股骨颈骨密度T值,对结果进行分析并将入选人群分为骨量正常组、减少组、疏松组;同时进行血脂、血糖等生化指标测定.将86例患者按代谢综合症诊断标准分为正常组及对照组,观察各组骨质疏松发病率.结果骨量减少、骨质疏松组血脂、血糖等生化代谢指标显著高于正常组,血清脂联素水平显著低于正常组(P<0.05).血清脂联素以及甘油三酯、胰岛素抵抗等生化指标分别进入以骨密度T值和脂联素为自变量的多元逐步回归方程(P<0.05).代谢综合征组骨质疏松发病率(59%)高于对照组(32%),P<0.05.结论骨质疏松-脂联素-代谢综合征是一个以脂联素为联系枢纽、多因素参与的综合病变过程.分析代谢综合征作为代谢紊乱症候群,是骨质疏松发生的高风险因素.
Objective To explore the association of metabolic syndrome and bone metabolism. Methods All subjects were enrolled from inpatients who underwent osteoporosis. We studied total of 86 patients. Measurement bone mineral density(BMD) of the lumbar spine,femoral neck and left forearm with Dual Energy X-ray Absorptiometry were performed. Divided into three groups according to bone mineral density: normal, dsreduced bone mass and osteoporosis, fasting blood glucose with RIA meanwhile were recorded TG, HDL and other biochemical markers. Results FPG, TG and so on were higher than in normal group, Serum adiponectin levels in dsreduced bone mass group and osteoporosis group were lower than in normal group(P<0.05). In stepwise multiple linear regression analysis APN, TG, HOMA-IR could enter into the equation(P<0.05). Incidence of osteoporosis was higher than the control group. Conclusion TG and HOMA-IR are influencial factors of osteoporosis, Metabolic syndrome as the aggregate of multiple metabolic disorders was prone to osteoporosis.

OsteoporosisMetabolic syndromeAdiponectin

周波、张辉、高超

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277300 山东省枣庄市市立医院

骨质疏松 代谢综合征 脂联素

2013

中国医疗前沿
中国医院协会

中国医疗前沿

影响因子:0.186
ISSN:1673-5552
年,卷(期):2013.(7)
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