The study of establishing fatty liver VX2 tumor model in rabbit
Objective To explore establishing method of VX2 tumors in fatty 1iver and normal liver, Aimed at providing the basis for clinical fatty liver cancer research. Methods 34 rabbits were randomly divided into fatty 1iver group(n=18) and control group(n=16), Animals in fatty group were feeding high-fat diet and drinking water containing 5% ethanol, Animals in control group were feed regular diet and water. The model of fatty liver and normal liver VX2 tumor in rabbit were established, furthermore, compared with pathologic histology. Results ⑴Models of fatty 1iver disease could be established in rabbits by feeding them high-fat and alcohol drink, which the success rate was 100%. ⑵The successful rate of implantation VX2 tumor in fatty liver and normal liver of rabbit was 89.7%.⑶Measurements of tumor using contrast-enhanced ultrasound were consistent with pathology, showed no significant difference(P>0.05). Conclusion The animal model of fatty liver established by being fed a high-fat and alcohol diet was similar as human pathophysiological process fatty liver. The method implanting VX2 tumor lump to rabbit fatty liver was easy reproduction and high success rate.
NETL
NSTL
万方数据
维普
