舌鳞癌组织中Livin、Caspase-3的表达及意义
Expression and clinicopathological significance of Livin and Caspase-3 in tongue squamous cell carcinoma
邓星辉 1黎红 1周伟 1余卫东1
作者信息
- 1. 529030 广东省江门市中心医院病理科
- 折叠
摘要
目的探讨Livin、Caspase-3在舌鳞癌发生发展中的作用.方法采用免疫组化SP法检测48例舌鳞癌组织Livin、Caspase-3的表达,分析其与舌鳞癌临床病理特征的关系.结果 Livin、Caspase-3在舌鳞癌组织中的表达阳性率分别为58.33%(28/48)、43.75%(21/48)；与正常舌粘膜组织比较,舌鳞癌组织Livin阳性表达率显著升高(P<0.05),Caspase-3阳性表达率显著降低(P<0.05)；舌鳞癌组织Livin、Caspase-3表达与肿瘤TNM分期、组织学类型及淋巴结转移有关(P<0.05),与患者年龄,性别无关；Livin与Caspase-3的表达呈负相关(r=-0.362,P<0.05).结论 Livin、Caspase-3在舌鳞癌的发生发展过程中起着重要作用.
Abstract
Objective To investigate the expression of Livin and Caspase-3 in tongue squamous cell carcinoma(TSCC) and their clinicopathological significance. Methods The expression of Livin and Caspase-3 was detected in 48 cases of TSCC and 12 cases of normal tongue mucosa by immunohistochemistry. Result The positive expression rate of Livin in TSCC was 58.33%(28/48) and significantly higher than that in normal tongue mucosa(P<0.05). The positive expression rate of Caspase-3 in TSCC was 43.75%(21/48), and significantly lower than that in normal tongue mucosa(P<0.05). Overexpression of Livin and underexpression of Caspase-3 was related to tumor TNM stage, histological grade, cervical lymphatic metastasis(P<0.05). There was a negative correlation between them(r=-0.362, P<0.05). Conclusions Livin and Caspase-3 may play an important role in the development, invasion and metastasis of TSCC.
关键词
舌鳞癌/Livin/Caspase-3/免疫组化Key words
Tongue squamous cell carcinoma/Livin/Caspase-3/Immunohistochemistry引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据