摘要
目的了解急性脑梗死患者脑微出血(CMB)的发生率，分析其危险因素。方法选择2008年3月-2012年3月住院的急性脑梗死患者122例，行MRI磁敏感加权成像，根据有无CMB分为两组，对其一般临床资料和临床生化指标进行比较，探讨急性脑梗死合并CMB的相关危险因素；根据CMB的程度分为三组，分析颈动脉内膜增厚与CMB程度之间的关系。结果CMB组血清HDL水平显著性高于非CMB组(P<0.05)，LDL水平显著性低于非CMB组(P<0.05)。年龄、高血压、脑卒中史、吸烟史在CMB组中的比例显著性高于非CMB组，差异有统计学意义(P<0.05)。CMB患者颈动IMT异常率显著性高于无CMB组(χ2=7.05，P<0.05)，并且在轻、中、重三组中IMT异常率也具有显著差异(χ2=8.83，P=0.02)。结论在急性脑梗死患者中，CMB发生与年龄、高血压、脑卒中史、吸烟史、颈动脉内膜增厚、血清HDL及LDL水平相关。
Abstract
Objective To investigate the incidence of cerebral microbleeds(CMB) in patients with acute cerebral infarction and analyze its risk factors. Methods 122 patients with acute cerebral infarction admitted to our hospital from March 2008 to March 2012 were divided into CMB group(n=51) and non-CMB group(n=71) according to their MRI susceptibility-weighted imaging. General clinical data and biochemical variables were compared between two groups to explore relative risk factors of CMB. The patients were divided into three groups according to the extent of the CMB, and the relationship between carotid IMT level and the degree of CMB were analysised. Results The LDL levels were significantly lower while the HDL level was significantly higher in CMB group than non-CMB group(P<0.05). The proportion of age, hypertension, stroke history and history of smoking in the CMB groups were significantly higher than the non-CMB group(P<0.05). The abnormal rate of IMT in CMB group were significantly higher than the non-CMB group(χ2=7.05, P<0.05), and The abnormal rate of IMT among mild, moderate and severe CMB groups also have a significant difference(χ2=8.83, P=0.02). Conclusion Age, hypertension, stroke history, smoking history, intimal thickening in the carotid artery, serum HDL and LDL levels are all risk factors for CMBs.
NETL
NSTL
维普
万方数据