Investigations on the white matter abnormalities in adult patients with migraine without aura before and after treatment & nbsp;with diffusion tensor magnetic resonance imaging
Objective To investigate the possible microstructural abnormalities of the cerebral white matter and its changes in adult patients with migraine without aura before and after treatment. Methods Diffusion tensor magnetic resonance imaging(DT-MRI) was carried out in 32 adult patients with migraine without aura and 32 age- and sex- matched healthy controls. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) were measured at genu, body, and splenium of the corpus callosum(CC) and bilateral frontal white matter, respectively. Results The FA values at the genu, body, and splenium of the CC from patients with migraine without aura before treatment were significantly lower than the control(P<0.01). The FA values at the genu, body, and splenium of the CC after treatment all increased significantly compared with before treatment(P<0.01). However, the FA values at the bilateral frontal white matter were not significant different between the two groups(P>0.05). The ADC values of the above regions were not significantly different between the two groups(P>0.05). There were negative correlations between disease course and the FA values at the genu, body, and splenium of the CC(r=-0.743, -0.742, and -0.363, P=0.000, 0.000, and 0.009, respectively). Negative correlations were also found between headache frequency and FA values at the genu and body of the CC(r=-0.824, and -0.792, P=0.000, and 0.000, respectively). Conclusion There might be an integrity change of neurofibrotic microstructures in the CC in adult patients with migraine without aura, which may be reversible through effective treatment.
MigraineDrug treatmentCerebral white matterDiffusion tensor magnetic resonance imaging
NETL
NSTL
万方数据
维普
