摘要
目的应用流式细胞仪检测一期梅毒(PS)外周血淋巴细胞亚群，了解机体在梅毒早期感染时细胞免疫改变，为临床治疗提供理论依据。方法19名志愿者应用流式细胞术检测外周血CD3+、CD4+、CD8+淋巴细胞亚群，其中PS组7例，正常对照组12例。结果 PS组CD3+、CD4+、CD8+和CD4+/CD8+均高于对照组，但没有统计学意义(P>0.05)。随溃疡的出现，CD4+/CD8+在溃疡的第1周内低于下正常平均值，第2周高于正常平均值，并且逐步明显升高。结论随着生殖器溃疡的出现，PS的细胞免疫可以被抑制也可以增强，第1周是被抑制，第2周增强。
Abstract
Objective Flow cytometric were applied to detect T lymphocyte subpopulations in patients infected with primary syphilis, to know the change of cell-mediated immunity and to offer theory base to clinical treatment. Methods Flow cytometric were applied to detect CD3+, CD4+ and CD8+ lymphocyte in peripheral blood from 19 volunteers, including 7 patients infected with primary syphilis and 12 normal human. Results Although CD3+, CD4+, CD8+ and CD4+/CD8+ were higher in primary syphilis , but there were not significant(P>0.05). With ulcer appearing, CD4+/CD8+ were lower in the first week but higher in the second than normal average value. Conclusions With ulcer appearing, Cytoimmunity in primary syphilis can be depress or enhance. Cytoimmunity depresses in first week and enhances in second week.
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维普
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