The association of pl6, p21, p27 polymorphism with susceptibility to ovarian cancer
Objective To study the association of pl6, p21, p27 polymorphism with susceptibility to ovarian cancer. Methods 120 patients with epithelial ovarian cancer in our hospital during March 2007 to April 2011 were selected to study, and 120 healthy women as a control group. Results There were no significant difference(P>0.05) between the frequency of C/C, C/G and G/G genotype in p16 C540G gene of ovarian cancer patients and the control group; there were no significant difference(P>0.05) between the frequency of C/C, C/G and G/G genotype in p16 C580T gene of ovarian cancer patients and the control group; there were no significant difference(P>0.05) between the frequency of C/C, C/G and G/G genotype in p21 gene of ovarian cancer patients and the control group; there wase a significant difference(P<0.05) between the frequency of V/V, V/G and G/G genotype in p27 gene of ovarian cancer patients and the control group. Conclusion Some association of pl6 and p21polymorphism with susceptibility to ovarian cancer, and we found the V/V homozygous of p27 gene may increase the risk of ovarian cancer. It should be concerned in clinical diagnosis.
NETL
NSTL
万方数据
维普
