Objective We simultaneously detected CCP-Ab, AKA-Ab and RF to confirm their sensitivity, specificity and significance in rheumatoid arthritis(RA) patients, to provide clinical application in early diagnosis. Methods We used ELISA to detect CCP-Ab, immune indirect fluorescence assay for detection of AKA-Ab, scattering immunoturbidimetry for detection of RF. Results Sensitivity and specificity of CCP-Ab, AKA-Ab and RF were 56.99%, 96.34%; 43.01%, 95.1%and 58.06%, 56.09%, respectively. Percentage of CCP-Ab and AKA-Ab positive patients in different content of RF positive range was not significantly different. However, results of CCP-Ab and AKA-Ab were highly correlated. Conclusion In the early diagnosis of RA, combination of CCP-Ab and AKA-Ab will be more helpful for clinical patients.
NETL
NSTL
万方数据
维普
