MUC1及MMP-7在食管癌组织中的表达及其临床意义研究
盛守寅 1刘利松 1殷瑞忠 1闵长国 1邓健1
作者信息
- 1. 332000 江西省九江市第三人民医院外二科
- 折叠
摘要
目的探讨MUC1及MMP-7在ESCC发生发展中的作用及其临床意义。方法应用免疫组化(IHC)法测定84例癌组织及22例相应癌旁组织标本中MUC1和MMP-7蛋白表达水平，并分析其与临床病理资料之间的关系。结果 ESCC癌组织标本中MUC1和MMP-7的阳性表达率分别为66.67%(56/84)和53.57%(45/84)，癌旁组织阳性表达率分别为18.18%(4/22)和4.55%(1/22)相比，差异均有统计学意义(P <0.01)；MUC1与MMP-7表达呈显著正相关(r=0.608，P <0.01)。结论 MUC1和MMP-7在ESCC中高表达，可能与ESCC发展及侵袭转移有关。
Abstract
Objective Explore the MUC1 and MMP-7 inesophageal carcinoma development and its clinical significance. Methods By immunohis-tochemistry(IHC) method we determined 84 cases of cancer tissue and 22 cases of neighboring noncancerous tissue samples of MUC1 and MMP-7 protein expression levels. We found the relationship between the degree of differentiation and other clinical and pathological features. Results Positive expression of MUC1 and MMP-7 respectively in the ESCC 66.67% and 53.57%, and positive expression rate of normal control group 18.18% and 4.55%than the differences were statistically significant(P <0.01); and invasive depth related(r=0.608, P <0.01). Conclusion The expression of MUC1 and MMP-7 in postoperative ESCC levels associated with development and invasion and metastasis of ESCC, as an important reference to ESCC biological behavior and prognosis indicators to judge the development direction of ESCC is of great value.
关键词
食管鳞状细胞癌/MUC1/MMP-7/免疫组织化学Key words
ESCC/MUC1/MMP-7/Munohistochemistry引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据