Impact of obstructive sleep apnea on homocysteine in type 2 diabetic patients
Objective To investigate the impact of OSA(obstractive sleep apnea) syndrome on homocysteine in type 2 diabetic patients for better understanding the relationship of DM with OSAHS. Methods Those 140 DM patients with complete clinical data were divided into two groups according to their apnea-hypopnea indices(AHI): DM with OSAHS(n=78) and DM without OSAHS(n=62). General conditions, homocysteine and glycemic control parameters were detected and compared. And then, an analysis on the relation of sleep monitoring indices and Hcy was performed in the OSAHS group. Results The mean level of homocysteine was significantly higher in the OSAHS group than that in the non-OSAHS group(P <0.001), pearson correcation analysis revealed a positive correlation between the homocysteine level and severity of AHI, further multiple linear regression analysis showed that AHI were independent predictors of homocysteine level. Conclusion Patients with obstructive sleep apnea-hypopnea ayndrome complicated by type 2 diabetes have a high level of homocysteine,and had a positive correlation with OSAHS.
NETL
NSTL
万方数据
维普
