The Analysis of pregnant women’s coagulation function indicators and efficiency evaluation on diagnosis of postpartum hemorrhage
Objective To analyze the indicators of coagulation function in pregnant women and evaluate the correlation between the indicators of coagulation function in pregnant women and the postpartum hemorrhage. Methods 183 cases of pregnant women were selected from March 2011 to March 2012 in our hospital as the research object, 158 cases of healthy pregnant women were checked up in the same period in our hospital as the control group. Fibrinogen(Fg) level, prothrombin time(PT), thrombin time(TT), activate part of thrombin time(APTT), the d-dimmer and anticoagulant Ⅲ enzyme(AT-Ⅲ) activity of two groups were detected. Differences of laboratory parameters were analyzed within the two groups and between the group of maternal postpartum hemorrhage group and the non-bleeding group. Results The index of PT, TT was significantly shorten, AT-Ⅲ activity decreased significantly, the level of Fg and d-dimmer significantly higher than those in the control group, the difference were statistically significant(P <0.05). If the level of Fg≥7.00g/L was acted as the diagnosis level of postpartum hemorrhage, the positive predictive value(PPV) is 87.5% and the negative predictive value(NPV) is 82.3%. If the level of AT-Ⅲ ≤205mg/L, the PPV and NPV are 85.7% and 82.0% respectively. However, if the level of DD is above 650mg/L, the PPV and NPV are 100%. Conclusions The difference of coagulation parameters between the pregnant women and non-pregnant women is significant, it is important to predict postpartum hemorrhage according to the prenatal detection level of Fg, DD and AT-Ⅲ.
NETL
NSTL
万方数据
维普
