Objective Sharing the nursing experience for ophthalmoxerosis patients with liver diseases. Methods Nursing data including general nursing, medication instruction, diet intervention, targeted suggestion and specific nursing were collected and analyzed from patients who were diagnosed with liver diseases in our hospital and were suffering from and treated with ophthalmoxerosis in ophthalmology center from January to May in 2011. Results Ophthalmoxerosis symptoms were all relieved in total 31 patients(62 eyes). Conclusion The holistic nursing is crucial for ophthalmoxerosis treatment.