Clinical research on bacterial lysates in prevention of acute exacerbation of chronic obstructive pulmonary diseases
Objective To observe the preventive effects of bacterial lysates for acute exacerbation of chronic obstructive pulmonary diseases(AECOPD). Method 76 patients with AECOPD were randomly divided into two groups: 38 cases in control group were given conventional anti-inflammatory, relieving asthma, resolving phlegm and symptomatic treatment, The observation group 38 cases on the basis of routine treatment for bacterial lysates to oral; Observation of 2 groups of patients within 1 years the number of acute attack, antibiotic use time, peripheral blood T lymphocyte subgroups and serum immunoglobulin changes, and compare. Results The observation group 1 years the number of acute attack, during an acute episode of antibiotics use time are shorter than in control group(P <0.01), The observation group 6 months after peripheral blood T lymphocyte subsets and IgG, IgA levels before and after treatment had significant difference(P <0.05), The control group before and after treatment there was no statistically significant difference(P >0.05). Conclusion Application of bacterial lysates to treatment could obviously improve the chronic obstructive pulmonary disease immune function, reduce the infection of acute episodes.
NETL
NSTL
万方数据
维普
