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口腔鳞癌中MMP-1、MMP-2、uPA的表达与肿瘤侵袭和转移的关系

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目的探讨基质金属蛋白酶-1、2(MMP-1、MMP-2)及尿激酶型纤溶酶原激活物(uPA)的表达与口腔鳞癌侵袭和转移的关系。方法选取我院收治的60例口腔鳞癌患者，用免疫组化检测癌旁正常组织和癌组织中MMP-1、MM P-2、uPA的含量并进行比较。结果口腔鳞癌患者肿瘤组织与口腔癌旁正常组织MMP-1、MMP-2、uPA的含量有统计学差异(P <0.05)。结论口腔鳞癌中MMP-1、MMP-2、uPA的表达与肿瘤的侵袭、转移有着密切的关系，有可能成为评价肿瘤侵袭、转移程度的指标。
The relationship between oral squamous cell carcinoma of MMP-1, MMP-2, UPA's expression of tumor invasion and metastasis
Objective To investigate the relationship between MMP-1, MMP-2, UPA's expression in oral squamous cell carcinoma invasion and metastasis, to provide experimental evidence for tumor treatment and prognosis. Methods 60 patients with oral squamous cell carcinoma patients in our hospitalwere for the study, immunohistochemical detection of adjacent normal tissue and cancer tissue in MMP-1, the MM P -2, UPA's content. Results Patients with oral squamous cell carcinoma tumor cavity adjacent normal tissue MMP-1, MMP-2, the UPA's content difference were significant(P <0.05). Conclusion Oral squamous cell carcinoma of MMP-1, MMP-2, UPA's expression in tumor invasion and metastasis are closely related, it is possible to become the evaluation of invasion, metastasis indicators.

Oral squamous cell carcinomaMMP-1MMP-2uPAInvasion and metastasis

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734500 甘肃省张掖市民乐县人民医院口腔科

口腔鳞癌 MMP-1 MMP-2 uPA 侵袭和转移

2013

10.3969/j.issn.1673-5552.2013.12.0009

中国医疗前沿
中国医院协会

中国医疗前沿

影响因子：0.186
ISSN：1673-5552
年,卷(期)：2013.(12)
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