Effects of nicardipine,hydroxyethyl starch combined with volume expansion on propofol dosage during total intravenous anesthesia
Objective To investigate the effects of nicardipine hydroxyethyl starch combined with volume expansion on propofol dosage during total intravenous anesthesia. Methods 87 patients undergoing spinal surgery were randomly divided observation group(47 cases) and control group(40 cases). All patients received volume expansion with hydroxyethyl starch 10ml/kg in 20min after giving nicardipine. At 1 min before tracheal intubation,the patients were given a bolus of nicardipine 10μg/kg(observation group) or normal saline(control group), observation group received 10μg/kg nicardipine followed by infusion of 1μg·kg-1·min-1, while control group received the same volume of saline. Anesthesia was maintained with target-controlled by propofol BIS was contolled between 40-60. The consumption of propofol, recovery of consciousness and trachea extubation were recorded. Results The propofol dosage of observation group(850.7±139.3ml), waking hours(6.2±2.5) and extubation time(8.1±2.6) significantly less than in the control group, the difference was statistically significant(P <0.05); The observation group MAP average was 82.5±15.7, was obviously lower than the control group 93.5±17.6, it is statistically significant difference(P <0.05); Observation group HR averages 90.6±10.5, is significantly higher than control group 75.3±11.5, difference has statistical significance(P <0.05); Observation group intraoperative propofol concentration average and BIS average are 2.5±0.4μg/ml and 52.8±3.4, has difference with control group(P <0.05). Conclusion Nicardipine combined with hydroxyethyl starch on the volume expansion during induction could reduce cardiovascular respone, decrease propofol consumption and shorten the time of consciousness recovery and extubation in total intravenous anesthesia.
NETL
NSTL
万方数据
维普
