Bcl-2、PTEN和P53在非小细胞肺癌组织中的表达及相关性的研究
Expression and Correlation of Bcl-2、PTEN and P53 in Non-Small cell Lung Cancer
李红涛1
作者信息
- 1. 454002 河南省焦作市人民医院乳甲综合外科
- 折叠
摘要
目的探讨Bcl-2、PTEN和P53基因在非小细胞肺癌组织中的表达及与临床病理预后的关系。方法采用免疫组化S-P法检测96例非小细胞肺癌组织中Bcl-2、PTEN和P53蛋白的表达。结果⑴96例非小细胞肺癌组织中Bcl-2、PTEN和P53蛋白阳性表达总的阳性率分别为59.4%(57/96)、52.1%(50/96)和60.4%(58/96)。⑵Bcl-2蛋白的阳性表达在肺癌病理分级组间比较，差异有统计学意义(P <0.05)；与肺癌P-TNM分期组间比较，差异亦有统计学意义(P <0.05)。⑶PTEN、P53蛋白的阳性表达在肺癌P-TNM分期及淋巴结转移组间差异均有统计学意义(P <0.01)，PTEN在肺癌病理分级组间差异亦有统计学意义(P <0.01)。结论 Bcl-2、PTEN和P53基因在非小细胞肺癌的组织发生发展起着重要作用，三种基因蛋白产物的检测对非小细胞肺癌患者的预后评估有积极意义。
Abstract
Objective To explore the relationship among the expression of Bcl-2、PTEN and P53 gene and clinicopathological characteristics of non- small cell lung cancer. Methods 96 patients with non-small cell lung cancer were examined for Bcl-2、PTEN and P53 by immunohistochemical technique S-P method. Results ⑴The total positive rate of Bcl-2, PTEN and P53 protein are 59.4%(57/96), 52.1%(50/96) and 60.4%(58/96) in non-small cell lung cancer.⑵The positive rate of Bcl-2 protein expression was significant in patho-grade of non-small cell lung cancer(P <0.05);and the P-TNM stageing of lung cancer was also significant(P <0.05). ⑶The positive expression of the PTEN, P53 were significantly different among the P-TNM and lymph node metastasis(P <0.01), the positive expression of the PTEN was significantly different in patho-grade(P <0.01). Conclusions Bcl-2, PTEN and P53 gene was important in the development of non-small cell lung cancer. The detection for the three protein was significantly important for the prognosis of non-small cell lung cancer.
关键词
肺肿瘤/Bcl-2/PTEN/P53/免疫组织化学Key words
Lung neoplasms/Bcl-2/PTEN/P53/Immunohistoc-hemistry引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据