Investigations on the corpus callosum abnormalities in adult patients with generalized anxiety disorder with diffusion tensor magnetic resonance imaging
Objective The aim of this study was to investigate the possible microstructural abnormalities of the corpus callosum(CC) in adult patients with generalized anxiety disorder(GAD). Methods Diffusion tensor magnetic resonance imaging(DT-MRI) was carried out in 28 adult patients with GAD and 28 age- and sex- matched healthy controls. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) were measured at genu, body, and splenium of the CC, respectively. Results The FA values at the genu and body of the CC from patients with GAD were significantly lower than the control(P <0.01). However, the FA values at the splenium of the CC were not significant different between the two groups(P >0.05). The ADC values of the above regions were not significantly different between the two groups(P >0.05). There were negative correlations between disease course and the FA values at the genu and body of the CC(P <0.01). Negative correlations were also found between Hamilton anxiety scores and FA values at the genu and body of the CC(P <0.01). Conclusion There were integrity changes of neurofibrotic microstructures in the CC in adult patients with GAD, which can be detected by DT-MRI.
Generalized anxiety disorderCorpus callosumDiffusion tensor magnetic resonance imaging
NETL
NSTL
万方数据
维普
