Association between Polymorphism of HLA-DRB1、DQB1 and Injury of Liver Function from Rectal Cancer Chemotherapy
Objective To explore the related genes of Subsidiary-damage in tumor chemotherapy by the change of liver function index of patients with rectal cancer before and after chemotherapy and their correlation with the polymorphism of HLA-DRB1/DQB1. Methods Total 78 patients with rectal cancer were selected. The DNA of every patient were extracted and the polymorphism of their HLA-DRB1, HLA-DQB1 was detected by PCR-SSP. Meanwhile, each index before and after chemotherapy were detected, including TBIL, DBIL, TP, ALB, ALT, AST, ALP, GGT. Results HLA-DRB1*07 may be resistance gene of ALB、ALT injury; HLA-DRB1*08 may be resistance gene of ALB、ALT injury; HLA-DRB1*09 may be resistance gene of ALB、ALT injury; HLA-DRB1*12 may be resistance gene of ALB、ALT injury; HLA-DQB1*02 may be resistance gene of ALB, ALT injury; HLA-DQB1*05 may be resistance gene of ALB injury; HLA-DQB1*06 may be resistance gene of ALT injury and HLA-DQB1*06 may be sensitive gene of ALB injury. Conclusion HLA may be marker genes of secondary impair of tumour chems.
HLA-DRB1DQB1Rectal cancer chemotherapySubsidiary-injuryLaborartory parameters
NETL
NSTL
万方数据
维普
