首页|EGFR及Ki67在上皮性卵巢癌中的表达及意义

EGFR及Ki67在上皮性卵巢癌中的表达及意义

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目的探讨表皮生长因子受体(EGFR)和Ki67在上皮性卵巢癌中的表达及临床意义。方法采用免疫组化SP法检测EGFR和Ki67在上皮性卵巢癌、卵巢良性肿瘤和正常卵巢组织的表达情况。结果 EGFR和Ki67在上皮性卵巢癌组织与正常卵巢和卵巢良性肿瘤组织阳性的表达率有统计学差异(P<0.05)。EGFR和Ki67表达在肿瘤的组织学分级、临床分期和有无淋巴结转移中具有统计学差异(P<0.05)。结论 EGFR和Ki67在上皮性卵巢癌的发生、发展过程中起着重要的作用。
Expression and clinical significance of EGFR and Ki67 in epithelialovarian cancer
Objective To study the expression and clinical significance of EGFR and Ki67 in epithelial ovarian cancer. Methods The expression of EGFR and Ki67 in tissues of epithelial ovarian cancer, benign tumor and normal ovary were detected by SP immunohistochemistry. Results The positive expression rates of EGFR and Ki67 in epithelial ovarian cancer tissue were significantly different from those in normal ovary and ovarian benign tumors(P<0.05). The expression of EGFR and Ki67 in histological grade and clinical stage was significantly different(P<0.05). Conclusion EGFR and Ki67 play an important role in the development of epithelial ovarian cancer.

Epidermal growth factor receptor(EGFR)Ki67Immunohistochemistry

杨越、张蕾、崔瑶、杨家梅、沈叶

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465550 河南省信阳市新县人民医院妇产科

450003 郑州大学第二附属医院肿瘤科

表皮生长因子受体 Ki67 免疫组织化学

2013

中国医疗前沿
中国医院协会

中国医疗前沿

影响因子:0.186
ISSN:1673-5552
年,卷(期):2013.(14)
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