血清fPSA与tPSA比值对鉴别诊断前列腺癌的价值
The Differential and Diagnostic Value for Prostate Cancer of the Serum Free PSA and Total PSA Ratio
季广厚1
作者信息
- 1. 273200 山东省济宁市泗水县人民医院检验科
- 折叠
摘要
目的研究游离前列腺特异性抗原(fPSA)及总前列腺特异性抗原(tPSA)的比值(f/tPSA)对前列腺癌(PCa)鉴别诊断的价值。方法检测fPSA与tPSA并算出比值f/tPSA；同时算出不同f/tPSA所对应的特异性和敏感性。结果在4-10ng/ml的诊断灰区，PCa组与前列腺增生(BPH)组间血清中fPSA和tPSA的水平均无显著差异，而f/tPSA比值，PCa组(0.12±0.05)和BPH组(0.28±0.09)间差异显著(P<0.001)。结论在诊断灰区对前列腺癌的鉴别诊断，用f/tPSA比值比单独用tPSA及fPSA更有价值，诊断鉴别点以f/tPSA<0.19较为合适。
Abstract
Objective Research on the differential diagnostic value for prostate cancer(PCa) of the free PSA and total PSA ratio. Methods Detection of fPSA and tPSA and calculation of the ratio; and Calculates of the correspondent sensitivity and specificity of different f/tPSA. Results There is no significant difference between Pca group and BPH group in fPSA and tPSA, on the contrary, there is very significant difference between Pca group(0.12±0.05) and BPH group(0.28±0.09) in f/tPSA(P<0.001) in the diagnoses gray zone between 4-10ng/ml. Conclusion In the diagnoses gray zone, it is more effective to differentiate diagnose prostate cancer by means of f/tPSA ratio than by means of tPSA and fPSA, and it is more suitable to treat f/tPSA<0.19 as the diagnosis differentiation spot.
关键词
f/tPSA/诊断灰区/前列腺癌Key words
f/tPSA/Diagnoses Gray Zone/Prostate Cancer引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据