The Differential and Diagnostic Value for Prostate Cancer of the Serum Free PSA and Total PSA Ratio
Objective Research on the differential diagnostic value for prostate cancer(PCa) of the free PSA and total PSA ratio. Methods Detection of fPSA and tPSA and calculation of the ratio; and Calculates of the correspondent sensitivity and specificity of different f/tPSA. Results There is no significant difference between Pca group and BPH group in fPSA and tPSA, on the contrary, there is very significant difference between Pca group(0.12±0.05) and BPH group(0.28±0.09) in f/tPSA(P<0.001) in the diagnoses gray zone between 4-10ng/ml. Conclusion In the diagnoses gray zone, it is more effective to differentiate diagnose prostate cancer by means of f/tPSA ratio than by means of tPSA and fPSA, and it is more suitable to treat f/tPSA<0.19 as the diagnosis differentiation spot.