Association between Polymorphism of HLA-DRB1, DQB1 and changes of routine blood indexes from Rectal Cancer Chemotherapy
Objective To explore the related genes of Subsidiary-damage in tumor chemotherapy by the change of routine blood index of patients with rectal cancer before and after chemotherapy and their correlation with the polymorphism of HLA-DRB1/DQB1. Methods Total 78 patients with rectal cancer were selected. The DNA of every patient were extracted and the polymorphism of their HLA- DRB1, DQB1 was detected by PCR-SSP. Meanwhile, each index before and after chemotherapy were detected, including WBC、RBC、HGB、PLT、NEUT#、LYM# and so on. Results HLA-DRB1*07 may be resistance gene of RBC injury; HLA-DRB1*08 may be sensitive gene of LYM# injury; HLA-DRB1*09 may be resistance gene of RBC, HGB injury; HLA-DRB1*12 may be resistance gene of RBC、HGB injury; HLA-DQB1*02 may be resistance gene of RBC、HGB injury; HLA-DQB1*05 may be resistance gene of HGB injury and HLA-DQB1*05 may be sensitive gene of NEUT# injury; HLA-DQB1*07 may be resistance gene of RBC、HGB injury. Conclusion HLA may be marker genes of secondary impair of tumour chems.
HLA-DRB1DQB1Rectal cancer chemotherapySubsidiary-injuryLaborartory parameters
NETL
NSTL
万方数据
维普
