The efficacy and safety analysis of glibenclamide and metformin in the hospitalized patients with type 2 diabetes
Objective To explore the clinical application of glibenclamide and metformin on their efficacy and safety in hospitalized patients with type 2 diabetes. Methods 180 cases with type 2 diabetes were randomly divided into glibenclamide the phenylurea group and metformin group, each group has 90 cases. After 3 months of treatment, the FPG, 2hPG, HbAlc, blood pressure, blood lipid levels and BMI index were evaluated. Results After treatment, the indicators of this study were all decreased to some extent, but, there was no significant difference between the two groups; The HbA1c contents in glibenclamide group were decreased significantly that higher than the metformin group, whereas the hypoglycemia event rate in metformin group was significantly lower than that in the glibenclamide group. Conclusion Both glibenclamide and metformin have good hypoglycemic effect but they have their own advantages, and clinical guidance can depend on the purpose of the patient's medication.
Type 2 diabetesGlibenclamideMetforminEffectivenessSecurity
NETL
NSTL
万方数据
维普
