Rheumatoid factor and anti-cyclic citrullinated peptide antibodies Clinical application of combined detection
Objective To investigate the analysis of rheumatoid factor and anti-citrulline antibody combined detection for the clinical application value. Methods Using enzyme-linked immunosorbent assay(ELISA method) to our hospital for the treatment of 150 cases of rheumatoid arthritis(RA) patients(A group), 28 cases of non-RA patients(B group) and 34 cases of healthy people(C group) were detected in serum, compared three groups of serum rheumatoid factor, anti-citrulline antibody for use alone or in combination for the diagnosis of rheumatoid arthritis sensitivity, specificity and so on. Results A group of people for anti-citrulline antibodies and rheumatoid factor positive rate than the B group, C group high(P <0.01); A group of rheumatoid factor alone sensitive than anti-citrulline antibodies for the anti-citrulline antibody specificity for the above rheumatoid factor, combined use of anti-citrulline conversion and rheumatoid factor antibodies, the detection sensitivity and negative predictive values, and Youden index for other than anti-citrulline antibodies or rheumatoid factor when used alone. Conclusion Anti-changer citrulline antibody and rheumatoid factor used in combination for the diagnosis of rheumatoid arthritis with good clinical practice.
NETL
NSTL
万方数据
维普
