脑血管病与MTHFR基因A1298C多态的研究
Cerebrovascular disease and MTHFR gene A1298C polymorphism studies
董翔1
作者信息
- 1. 116011 大连医科大学附属第一医院神经内科
- 折叠
摘要
目的探讨脑血管病与MTHFR基因A1298C多态性关系。方法对我院脑血管病患者与健康体检者各100例作病例-对照研究。运用聚合酶连反应-限制性内切酶片段长度多态性分析(PCR-RFLP)方法确定MTHFR基因型。结果患者组中CC型与T等位基因频率、AC型与C等位基因频率均明显高于健康对照组(P<0.05)。结论 MTHFR1298AC型与C等位基因在脑血管疾病中的构成比均明显增大，MTHFR1298C多态性可能与脑血管疾病的发生存在一定的相关性。
Abstract
Objective To investigate the cerebrovascular disease and polymorphisms of MTHFR A1298C relationship. Methods 100 patients admitted to our hospital with 100 cases of cerebrovascular disease for healthy case-control study. Polymerase chain reaction-restriction fragment length polymorphism analysis(PCR-RFLP) method of MTHFR genotype to be determined. Results Patients with CC genotype and T allele were significantly higher than the control group(P<0.05). The group of patients with C allele frequency AC type were significantly higher than the control group(P<0.05). Conclusion MTHFR 1298AC type and C allele in the composition of cerebrovascular disease were significantly larger than that considered MTHFR1298C polymorphism may be associated with the incidence of cerebrovascular disease there is a certain correlation.
关键词
脑血管病/MTHFR基因/A1298C多态性Key words
Cerebrovascular disease/MTHFR gene/A1298C polymorphism引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据