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多索茶碱治疗慢性阻塞性肺病的疗效观察

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目的观察和评价多索茶碱用于慢性阻塞性肺疾病(COPD)的临床疗效。方法将63例COPD患者随机分为两组,治疗组使用多索茶碱300mg加入5%的葡萄糖注射液250ml静滴,1次/d,连续用药5d;对照组使用氨茶碱注射液,每次250mg加入5%葡萄糖250ml中静滴,1次/d,连续用药5d。观察对比两组患者用药后的临床症状、肺功能、血气变化和不良反应的发生率。结果治疗组总有效率高于对照组,差异有统计学意义;治疗前后肺功能各项指标差异有统计学意义,组间差异无统计学意义;治疗组不良症状发生率低于对照组,差异有统计学意义。结论与氨茶碱比较,多索茶碱的临床总有效率高、不良反应发生率低,治疗哮喘及慢性阻塞性肺病安全有效。
Objective To observe and appraise the effect of doxofylline injection for patients with COPD, bronchial asthma. Methods Comparison between doxofylline and anfylline 63 case of the remedial group were treated for five days with intravenous infusion of 300mg of doxofylline injection which was added to 250ml of glucose, once a day. The control group were treated for five days with intravenous infusion of 250mg of glucose, once a day. The clinical curative effect of two group of patients was compared in the post-treatment. The lung function parameters of two groups are compared after post-treatment. Result In the curative effect, the total effective rate was 96.88% in the doxofylline group and that was 81.25% in control group. In the untoward reaction effective rate was 6.25% in the doxofylline group and that was 25% in control group. There were significant differences between the doxofylline group and the control group(P<0.05). Conclusion Compare with anfylline, doxofylline has higher effective rate and lower untoward reaction rate, safe and effective for COPD.

DoxofyllineAsthmaCOPDEffect

李楠

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114001 鞍山,辽宁省鞍钢总医院

多索茶碱 哮喘 慢性阻塞性肺疾病 疗效

2013

中国医疗前沿
中国医院协会

中国医疗前沿

影响因子:0.186
ISSN:1673-5552
年,卷(期):2013.(16)
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