Objective To investigate the effects of saline enema in the treatment of pediatric intussusception under B-Mode Ultrasound. Methods Saline enema was performed in pediatric intussusception under B-Mode Ultrasound. Results Among 213 patients, 187 cases were reduction and 28 cases were given surgical treatment, no enterobrosis and death cases. Conclusion Saline enema procedure is safe and effective to treat acute intussusception in infants.