The values of Fetal fibronectin and insulin-like growth factor binding protein-1 in prediction of premature delivery
Objective To evaluate the clinical value of the fetal fibronection(fFN) and insulin-like growth factor binding protein-1(IGFBP-1) in prediction of premature delivery. Methods 210 cases of pregnant women with threatened abortion were randomly divided into three groups, each group have 70 cases. Qualitative detected fFN and IGFBP-1 in the cervical vaginal secretions by immunoassays. Group A only detected fFN and group B only detected IGFBP-1, group C detected fFN and IGFBP-1, observation delivery outcome within 1 week, 2 weeks.Then calculate the sensitivity, specificity, positive predictive value, negative predictive value and the diagnosis coincidence rate of each group. Results Group A have 19 positive cases and 51 negative cases. Group B have 21 positive cases and 49 negative cases. Group C have 33 positive cases either or both of fFN and IGFBP-1, and both of fFN and IGFBP-1 were negative 37 cases. Statistical analysis the prognostic sensitivity, specificity, positive predictive value, negative predictive value and the diagnosis coincidence rate within 7 days or 14 days among three groups, and there were no significant difference(P>0.05). Conclusion fFN and IGFBP-1 are effective predictors to predict premature delivery; The combined application of fFN and IGFBP-1 can improve the diagnosis coincidence rate.
NETL
NSTL
万方数据
维普
