Comparison of plasma NT-proBNP and echocardiographic parameters in Patients with mitral regurgitation
Objective The study aimed to compare plasma NT-proBNP and echocardiographic parameters in Patients with mitral regurgitation. Methods Total 55 patients with mitral regurgitation were enrolled in this study. Patients were divided into three groups according the severity of MR. Plasma concentration NT-proBNP, 2D and Doppler echocardiography were obtained from 55 patients with organic mild, moderate and severe MR. The areas under the ROC curves were used to evaluate the diagnostic performance of NT-proBNP and echocardiographic variables for the prediction of abnormality of MPI. Results NT-proBNP levels were increased with symptoms in patients with mitral regurgitation. The plasma NT-proBNP level were significantly correlated with MPI, and following echocardiographic indices: LVEDV, LVESV, LVEDD, LVESD, LAD and SPAP, and negative correlation with LVEF, dp/dt. An NT-proBNP serum level of 603pmol/l can show the abnormality of MPI with a sensitivity of 71.5% and a specificity of 73.2%. Conclusion Plasma NT-proBNP level has the same sensitivity and specificity as echocardiographic variables and may be used as a hormonal factor for the evaluation of patients with MR in combination with echocardiography.
NETL
NSTL
万方数据
维普
