Effect of gimeracil and oteracil porassium capsules combined with oxaliplatin in the treatment of advanced gastric cancer
Objective To observe therapeutic effect and safety of gimeracil and oteracil porassium capsules combined with oxaliplatin in the treatment of advanced gastric cancer. Methods All 30 cases were divided into two groups randomly, the trial group(15 cases), TS-1 capsule(80mg/m2)/d, twice a day peroral, d1-14; oxaliplatin 130mg/m2,intravenous drip, d1. The control groups(15 cases), tegafur 800mg/m2, intravenous drip, d1-5; CF 100mg,intravenous drip, d1-5;oxaliplatin 130mg/m2, intravenous drip, d1. One treatment cycle covered 3 weeks. The effects were evaluated after 2 cycles. Results The effective rate was 33.3% in the trial group, and 26.7% in the control group(P >0.05). The main toxicities were gastrointestinal reactions, bonemarrow toxicity and peripheral neurotoxicity. Conclusion TS-1 capsule combined with oxaliplatin is safe and effective in the treatment of advanced gastric cancer.
NETL
NSTL
万方数据
维普
