Diffusion-weighted MRI在家兔电烧伤后应用初步研究
Prelimiary study of Diffusion-weighted MRI after electrical burn in rabbits
欧志强 1陈松 1梁佩虹 1李振辉1
作者信息
- 1. 510220 暨南大学医学院第四附属医院/广州市红十字会医院放射科
- 折叠
摘要
目的：观察兔后肢电烧伤后磁共振弥散加权成像(MR-DWI)表面扩散系数(ADC)的变化规律。方法12只新西兰大白兔随机数字表法分为烧伤组及对照组，于电烧伤后24h、48h及72h行伤肢MRI扫描，DWI成像b值分别选取50s/mm2、100s/mm2、300s/mm2同时进行T2WI及T1WI扫描，组织病理学检查。结果各烧伤组ADC值低于对照组，在b=300mm2/s时，烧伤后48h病变组与对照组之间差异存在统计学意义(P <0.05)。结论采用b值弥散成像(DWI)能够监测肌肉烧伤后病理变化过程，ADC值可以作为检测烧伤程度的影像观察指标。
Abstract
Objective To observe apparent diffusion coefficient(ADC) changes after rabbits electric burn. Methods Twelve healthy New Zealand white rabbits were equally randomized into burn group and control groups(post-burn at 24, 48 and 72h respectively). They were imaged with a 1.5T MRI protocol to obtain T2WI, T1WI and DWI with ADC maps using b values of 50, 100, 300s/mm2, and histological examinations were conducted on burn muscles. Result The ADC of burn groups was lower than the control group. ADC of 48 h group were significantly lower than that of control group(P <0.05) when b=300s/mm2. Conclusion DWI is sensitive to characterize the histopathologic changes with b values and ADC may be a useful parameter in assessing degree of burn.
关键词
弥散加权成像/电烧伤/兔/磁共振成像Key words
Diffusion weighted imaging/Electrical burn/Rabbit/Magnetic resonance imaging引用本文复制引用
基金项目
出版年
2013
NETL
NSTL
维普
万方数据