首页|风寒咳嗽颗粒的质量标准研究

风寒咳嗽颗粒的质量标准研究

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目的：建立和完善风寒咳嗽颗粒质量标准。方法采用TLC法对处方中的桑白皮进行定性鉴别，并用HPLC法对处方中橙皮苷进行含量测定，采用CAPCELLPAK C18(5μm，4.6mm×250mm)色谱柱，以乙腈-0.2%磷酸(2080)为流动相，检测波长为283nm。结果薄层色谱斑点清晰，易于识别，专属性强；橙皮苷在0.25-1.52μg范围内呈良好的线性关系(r=0.9995)，平均回收率为100.2%，RSD为1.3%。结论该方法准确灵敏、简便，重复性好，提高后的质量标准能更有效地控制制剂质量。
Studies on Quality Standard of Fenghankesou Granules
Objective To determine and consummate the quality standard of Fenghankesou Granules. Methods Cortex mori in Fenghankesou Granules was identified by TLC. The content of Hesperidin was determined by HPLC. The chromatographic conditions were:CAPCELLPAK C18(5μm, 4.6mm×250mm) column, mobile phase being acetonitrile and 0.2% phosphoric acid(20 80), and the detection wavelength at 283nm. Results The qualitative identification with TLC were specific. Hesperidin showed a good linearity within the range of 0.25-1.52μg, r=0.9995, the average recovery was 100.2%, and RSD was 1.3%. Conclutions This method can be used for the quality control of Fenghankesou Granules.

Fenghankesou GranulesQuality controlTLCCortex moriHPLCHesperidin

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223300 江苏省淮安食品药品检验所

风寒咳嗽颗粒 质量标准 薄层色谱 桑白皮 高效液相色谱 橙皮苷

2013

10.3969/j.issn.1673-5552.2013.22.0072

中国医疗前沿
中国医院协会

中国医疗前沿

影响因子：0.186
ISSN：1673-5552
年,卷(期)：2013.(22)
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