Objective To observe the clinical efficacy and safety of enalapril and nifedipine on treatment of essential hypertension. Method According to a randomized, double-blind, controlled principle, 120 patients with essential hypertension were divided into A, B, C groups, patients in each group were given enalapril, nifedipine, and the two drugs in combination therapy individually, the antihypertensive effect and adverse reactions of the three groups were compared and analyzed. Results After 4 weeks treatment, the total effective rate of group A and B were significantly lower than that of group C(P<0.05);SBP and DBP values of group C were significantly lower than that of group A, group B of the same period, the difference were significant(P<0.05). Adverse reactions were mild in all patients, there was no statistical significance among the three groups(P>0.05). Conclusion Enalapril and nifedipine is effective in treating patients with essential hypertension antihypertensive with less adverse reactions, which is quite worthy of popularization and application.
NETL
NSTL
万方数据
维普
