摘要
目的：观察口服降糖药治疗2型糖尿病失效后，联合甘精胰岛素治疗糖尿病的疗效。方法筛选68例单用口服降糖药血糖控制不理想的2型糖尿病患者，睡前(2130)加用甘精胰岛素(来得时)，治疗14周，比较前后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹C肽、餐后2hC肽、体重变化及低血糖的发生。结果加用甘精胰岛素组治疗14周后，患者FPG、2hPG、HbA1c较治疗前明显下降(P<0.01)，餐后2hC肽较治疗前明显升高(P<0.01)，未见低血糖发生，体重指数影响不大。结论对单用口服药效果不佳的2型糖尿病，需及时加用甘精胰岛素治疗。
Abstract
Objective To observe the curative effect of combined with insulin therapy after failure treatment with oral hypoglycemic agents for type 2 diabetes. Method Screening 68 cases with oral hypoglycemic agents alone with no ideal blood sugar control in type 2 diabetes, patients bedtime(9 30 pm) plus insulin glargine(Lantus) treatment with 14 weeks treatment, compared before and after FPG, 2hPG, HbA1c, fasting C peptide, 2h postprandial C-peptide, weight changes and the occurrence of low blood sugar. Results Combined with insulin treatment after 14 weeks , patients’s FPG, 2hPG, HbA1c significantly decreased than that before treatment(P<0.01), and with postprandial 2h C-peptide significantly higher(P<0.01). Conclusion It should be timely combined with insulin after failure treatment with oral hypoglycemic agents alone for type 2 diabetes.
NETL
NSTL
维普
万方数据